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CME Accreditation Page and Author Disclosure
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iii
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Contributors
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v-vi
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Contents
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vii-x
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Forthcoming Issues
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xi
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Pediatric Rheumatology
29 March 2012
The pediatric rheumatic diseases comprise a diverse group of disorders that range from mild and self-limited (eg, transient synovitis) to devastating and fatal (eg, macrophage activation syndrome). Th...
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Ronald M. Laxer,
David D. Sherry
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xiii-xiv
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Principles of Inflammation for the Pediatrician
The immune system consists of 2 branches: innate and adaptive. The former represents the first line of host defense during infection and plays a key role in the early recognition and protection agains...
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Alessia Omenetti,
Sabrina Chiesa,
Marco Gattorno
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225-243
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Approach to the Child with Joint Inflammation
Arthritis is manifested as a swollen joint having at least 2 of the following conditions: limited range of motion, pain on movement, or warmth overlying the joint. This article discusses an approach t...
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Roberta Berard
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245-262
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Laboratory Testing in Pediatric Rheumatology
In children, laboratory evaluations can assist in the screening of patients for inflammatory disorders, confirm diagnoses, allow for monitoring of disease activity and response to therapy, and suggest...
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Jay Mehta
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263-284
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Rheumatologic Emergencies in Newborns, Children, and Adolescents
This article presents five clinical scenarios in which the initial manifestations of pediatric rheumatic diseases constitute life-threatening medical emergencies. It is intended as a problem-oriented ...
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Jonathan D. Akikusa
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285-299
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Juvenile Idiopathic Arthritis
Juvenile idiopathic arthritis (JIA) encompasses a complex group of disorders with arthritis as a common feature. This article provides the pediatrician with a review of the epidemiology, classificatio...
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Peter J. Gowdie,
Shirley M.L. Tse
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301-327
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Making Sense of the Cytokine Storm: A Conceptual Framework for Understanding, Diagnosing, and Treating Hemophagocytic Syndromes
Cytokine storm syndromes (CSS) are a group of disorders representing a variety of inflammatory causes. The clinical presentations of all CSS can be strikingly similar, creating diagnostic uncertainty....
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Scott W. Canna,
Edward M. Behrens
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329-344
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Systemic Lupus Erythematosus in Children and Adolescents
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of disease manifestations that can involve any organ system, and can lead to significant morbidity and even mortali...
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Deborah M. Levy,
Sylvia Kamphuis
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345-364
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Idiopathic Inflammatory Myopathies in Childhood: Current Concepts
The juvenile idiopathic inflammatory myopathies are a group of rare, chronic, multisystem, autoimmune diseases associated with muscle weakness. This article reviews practical issues of relevance to pe...
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Adam M. Huber
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365-380
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Pediatric Scleroderma: Systemic or Localized Forms
09 April 2012
Pediatric scleroderma includes 2 major groups of clinical entities, systemic sclerosis (SSc) and localized scleroderma (LS). Although both share a common pathophysiology, their clinical manifestations...
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Kathryn S. Torok
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381-405
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Pediatric Vasculitis
09 April 2012
Childhood vasculitis is a challenging and complex group of conditions that are multisystem in nature and often require integrated care from multiple subspecialties, including rheumatology, dermatology...
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Pamela F. Weiss
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407-423
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Kawasaki Disease
Kawasaki disease is a systemic vasculitis and the leading cause of acquired heart disease in North American and Japanese children. The epidemiology, cause, and clinical characteristics of this disease...
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Rosie Scuccimarri
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425-445
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Autoinflammatory Syndromes
There has been an expansion of the autoinflammatory syndromes due to the discovery of new diseases related to mutations in genes regulating the innate immune system and the knowledge gained from these...
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Philip J. Hashkes,
Ori Toker
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447-470
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Approach to the Patient with Noninflammatory Musculoskeletal Pain
Musculoskeletal pain is one of the most common presenting symptoms at the pediatrician's office. Etiology ranges from benign conditions to serious ones requiring prompt attention. This article address...
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Peter Weiser
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471-492
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Immunodeficiency Diseases with Rheumatic Manifestations
Most clinicians associate primary immunodeficiency disorders (PIDDs) with susceptibility to frequent or severe infections. It is less commonly recognized, however, that PIDDs are frequently associated...
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Troy R. Torgerson
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493-507
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Index
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509-531
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